Clinical evidence

Several clinical trials provide clinical evidence of a significant improvement in cardiac care and reduction in hospital stay ​with PAP-guided heart failure management.

MONITOR-HF clinical trial

Published: May 20, 2023
MONITOR-HF is the third randomized, controlled clinical trial globally confirming the significant health benefit and hospital cost savings of remote PAP monitoring for patients with moderate-to-severe HF.  (Ref 1,2,3,4)

Clinical evidence of improved quality of life and 44% reduction in HF hospitalizations

MONITOR-HF clinical trial enrolled 348 patients in 25 centers in the Netherlands

COAST clinical trial

COAST trial confirmed that hemodynamic-guided HF management, using remote PAP monitoring, significantly improves outcome and reduces hospitalizations for patients with symptomatic HF.  (Ref. 6) 


COAST clinical trial enrolled 300 patients at 14 specialist centers in the UK

CHAMPION clinical trial 

CHAMPION trial has shown that remote PAP–guided HF management leads to a 49% reduction in HF hospitalizations  and a 58% reduction in 30-day readmissions compared to the standard of care.  (Ref. 7,8,9)


CHAMPION clinical trial enrolled 550 patients in the US

References

1. ​Brugts JJ et al. Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF trial): a randomised clinical trial. Lancet. 2023 May 20. doi: 10.1016/S0140-6736(23)00923-6
2. Brugts JJ et al. A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS on quality of life and hospitalisations in heart failure patients (MONITOR-HF trial). 2020 Jan 28. doi: 10.1007/s12471-019-01341-9
3. ESC press release. 20 May 2023 - Remote monitoring reduces heart failure hospitalisations and improves quality of life - results from MONITOR-HF trial
4. Abbott press release. 24 May 2023 - European Study Finds the Abbott CardioMEMS Sensor Results in Improved Quality of Life and 44% Reduction in HF Hospitalizations
5. Cowie MR et al. Real-world evidence in a national health service: results of the UK CardioMEMS Post-Market Study (COAST trial). ESC HF. 2022 Feb 9. doi: 10.1002/ehf2.13748.
6. Brugts JJ et al. Clinical Update of the Latest Evidence for CardioMEMS Pulmonary Artery Pressure Monitoring in Patients with Chronic HF: A Promising System for Remote HF Care. Sensors (Basel). 2021 Mar 27. doi: 10.3390/s21072335
7. Abraham WT et al. Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomized control study (CHAMPION trial). Lancet. 2011 Feb 19;377(9766):658-66
8. Adamson PB et al. Pulmonary Artery Pressure–Guided Heart Failure Management Reduces 30-Day Readmissions (CHAMPION trial). Circ Heart Fail. 2016;9:e002600.  ​
9. Abraham, WT et al. Pulmonary artery pressure management in heart failure patients - significantly reduces heart failure hospitalizations and mortality. vol. 65 no. 10, ACC 2015